反应详情

Using similar reaction conditions as described in step-iii of example-1, tert-butyl 4-(4-(3-(1-(3,5-difluorobenzyl)-1H-pyrazol-3-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperazine-1-carboxylate (55 mg, 0.0759 mmol) was hydrolyzed by lithium hydroxide (10 mg, 0.227 mmol) in THF/methanol/water (2/2/1 ml) to yield 15 mg (34.6% yield) of the titled compound.

1. customreaction conditions