反应详情

Using similar reaction conditions as described in step-iii of example-1, 3-(1-phenethyl-1H-pyrazol-4-yl)-5-(6-(piperazin-1-yl)pyridin-3-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine (55 mg, 0.09 mmol) was hydrolyzed with lithium hydroxide (20 mg, 0.45 mmol) in THF/methanol/water (2/1/1 mL) to yield 40 mg (100% yield) of desired product. 1H NMR (CD3OD, 300 MHz): δ 8.51-8.50 (d, 1H), 8.43 (s, 1H), 8.25-8.15 (dd, 1H), 7.91-7.86 (d, 2H), 7.68 (s, 1H), 7.27-7.21 (m, 3H), 7.14-7.12 (m, 3H), 4.50-4.40 (t, 2H), 3.97-3.94 (t, 4H), 3.43-3.34 (t, 4H), 3.20-3.18 (t, 2H). MS: m/z=450.4 (M+1), HPLC: 92.83% in method A.

1. customreaction conditions