HCID 118524030, compound → HCID 118524098, compound

HRID 531779Notes

Reaction equation

HRID 531779 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:51]=[CH:52][CH:53]=1)[CH2:5][N:6]1[CH:10]=[C:9]([C:11]2[C:19]3[C:14](=[N:15][CH:16]=[C:17]([C:20]4[CH:21]=[CH:22][C:23]([N:28]5[CH2:33][CH2:32][N:31](C(OC(C)(C)C)=O)[CH2:30][CH2:29]5)=[N:24][C:25]=4[O:26][CH3:27])[CH:18]=3)[N:13]([S:41]([C:44]3[CH:50]=[CH:49][C:47]([CH3:48])=[CH:46][CH:45]=3)(=[O:43])=[O:42])[CH:12]=2)[CH:8]=[N:7]1>CO.Cl.O1CCOCC1>[F:1][C:2]1[CH:3]=[C:4]([CH:51]=[CH:52][CH:53]=1)[CH2:5][N:6]1[CH:10]=[C:9]([C:11]2[C:19]3[C:14](=[N:15][CH:16]=[C:17]([C:20]4[C:25]([O:26][CH3:27])=[N:24][C:23]([N:28]5[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]5)=[CH:22][CH:21]=4)[CH:18]=3)[N:13]([S:41]([C:44]3[CH:50]=[CH:49][C:47]([CH3:48])=[CH:46][CH:45]=3)(=[O:43])=[O:42])[CH:12]=2)[CH:8]=[N:7]1

Participants

4

Reactant 1

HCID 118524030HCID 118524030, compound

Product 1

HCID 118524098HCID 118524098, compoundYield 90.6%

Reagents, catalysts & solvents 2

HCID 312751,4-DioxaneSolventHCID 21893726Hydrochloride methanolSolvent

Procedure

Using similar reaction conditions as described in step-ii of example-7, tert-butyl 4-(5-(3-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-6-methoxypyridin-2-yl)piperazine-1-carboxylate (67 mg, 0.090 mmol) was deprotected in methanol/HCl in dioxane (2/5 ml) to afford 52 mg (89% yield) of the titled compound. MS: m/z=638.2 (M+1).

Workup

  1. customreaction conditions

Sources & evidence

ORD record
ord-dcffbabe3ec54f76bb789ef361fac0ab
Source dataset
uspto-grants-2016_05
Patent number
US09353107B2

Reaction notes

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