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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 531779Generated: October 31, 2026

HCID 118524030, compound → HCID 118524098, compound

https://huagongshe.com/reaction/531779

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 118524030HCID 118524030—
Solvent1,4-DioxaneHCID 31275—
SolventHydrochloride methanolHCID 21893726—
ProductHCID 118524098HCID 11852409890.6%

Reaction Steps

Using similar reaction conditions as described in step-ii of example-7, tert-butyl 4-(5-(3-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-6-methoxypyridin-2-yl)piperazine-1-carboxylate (67 mg, 0.090 mmol) was deprotected in methanol/HCl in dioxane (2/5 ml) to afford 52 mg (89% yield) of the titled compound. MS: m/z=638.2 (M+1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09353107B2
Source datasetuspto-grants-2016_05
ORD IDord-dcffbabe3ec54f76bb789ef361fac0ab
Source noteuspto-grants-2016_05