HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 118524030, compound → HCID 118524098, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 118524030 | HCID 118524030 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Solvent | Hydrochloride methanol | HCID 21893726 | — |
| Product | HCID 118524098 | HCID 118524098 | 90.6% |
Reaction Steps
Using similar reaction conditions as described in step-ii of example-7, tert-butyl 4-(5-(3-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-6-methoxypyridin-2-yl)piperazine-1-carboxylate (67 mg, 0.090 mmol) was deprotected in methanol/HCl in dioxane (2/5 ml) to afford 52 mg (89% yield) of the titled compound. MS: m/z=638.2 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09353107B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-dcffbabe3ec54f76bb789ef361fac0ab |
| Source note | uspto-grants-2016_05 |