HRID531825
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
PROCEDURE
实验过程
Using similar reaction conditions as described in step-iii of example-1, (S)-1-(4-(5-(3-(1-(3-fluorobenzyl)-5-methyl-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridin-2-yl) piperazin-1-yl)propan-2-ol (350 mg, 0.51 mmol) was hydrolyzed with lithium hydroxide (65 mg, 1.54 mmol) in THF/methanol/water (6/4/2 mL) to yield 40 mg (11% yield) after purification by preparative HPLC as a mixture of two isomers. MS: m/z=526.5 (M+1). HPLC: 89.1% in method B.
WORKUP
后处理
- customreaction conditions
- customto yield 40 mg (11% yield)
- customafter purification by preparative HPLC
- additionas a mixture of two isomers