HCID 118524119, compound → HCID 118524034, compound

HRID 531829Notes

Reaction equation

HRID 531829 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:50]=[CH:51][CH:52]=1)[CH2:5][N:6]1[CH:10]=[C:9]([C:11]2[C:19]3[C:14](=[N:15][CH:16]=[C:17]([C:20]4[CH:25]=[CH:24][C:23]([N:26]5[CH2:32][CH2:31][CH2:30][N:29](C(OC(C)(C)C)=O)[CH2:28][CH2:27]5)=[CH:22][CH:21]=4)[CH:18]=3)[N:13]([S:40]([C:43]3[CH:49]=[CH:48][C:46]([CH3:47])=[CH:45][CH:44]=3)(=[O:42])=[O:41])[CH:12]=2)[CH:8]=[N:7]1>C(O)(C(F)(F)F)=O.C(Cl)Cl>[N:26]1([C:23]2[CH:24]=[CH:25][C:20]([C:17]3[CH:18]=[C:19]4[C:11]([C:9]5[CH:8]=[N:7][N:6]([CH2:5][C:4]6[CH:50]=[CH:51][CH:52]=[C:2]([F:1])[CH:3]=6)[CH:10]=5)=[CH:12][N:13]([S:40]([C:43]5[CH:44]=[CH:45][C:46]([CH3:47])=[CH:48][CH:49]=5)(=[O:42])=[O:41])[C:14]4=[N:15][CH:16]=3)=[CH:21][CH:22]=2)[CH2:32][CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1

Participants

3

Reactant 1

HCID 118524119HCID 118524119, compound

Product 1

HCID 118524034HCID 118524034, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 21863450Trifluoroacetic acid methylene chlorideSolvent

Procedure

Using similar reaction conditions as described in step-ii of example-7, tert-butyl 4-(4-(3-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)-1,4-diazepane-1-carboxylate (120 mg, 0.166 mmol) was deprotected in TFA/DCM (3/1 ml) to afford 100 mg (97.0% yield) of the titled compound. MS: m/z=621.2 (M+1).

Workup

  1. customreaction conditions

Sources & evidence

ORD record
ord-d3dcdf4898c4470a97b3226eb94e2e71
Source dataset
uspto-grants-2016_05
Patent number
US09353107B2

Reaction notes

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