反应详情

Using similar reaction conditions as described in step-iii of example-1, tert-butyl 4-(2-fluoro-4-(3-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperazine-1-carboxylate (product of step 1 of example 114) (120 mg, 0.165 mmol) was hydrolyzed with lithium hydroxide (35 mg, 0.827 mmol) in THF/methanol/water (5/5/2 mL) to afford 80 mg (85% yield) of the titled compound. MS: m/z=571.6 (M+1).

1. customreaction conditions