反应详情

Using similar reaction conditions as described in step-iii of example-1, tert-butyl 4-(2-fluoro-4-(3-(1-(3-fluorobenzyl)-3,5-dimethyl-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperidine-1-carboxylate (200 mg, 0.265 mmol) was hydrolyzed by lithium hydroxide (56 mg, 1.329 mmol) in THF/methanol/water (5/3/1 mL) to yield 110 mg (69.6% yield) of the titled compound. MS: m/z=598.5 (M+1).

1. customreaction conditions