反应详情

Using similar reaction conditions as described in step-iii of example-1, tert-butyl 4-(4-(3-(1-(3,5-difluorobenzyl)-1H-pyrazol-3-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-(methylsulfonamido)phenyl)piperidine-1-carboxylate (200 mg, 0.245 mmol) was hydrolyzed by lithium hydroxide (52 mg, 1.225 mmol) in THF/methanol/water (3/5/2 mL) to yield 110 mg (66.6% yield) of the titled compound. MS: m/z=662.8 (M+1)

1. customreaction conditions