反应详情

Using similar reaction conditions as described in step-iii of example-1, tert-butyl (5-(3-(1-(3,5-difluorobenzyl)-3,5-dimethyl-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-3-methoxypyridin-2-yl)carbamate (200 mg, 0.279 mmol) was hydrolyzed by lithium hydroxide (118 mg, 2.798 mmol) in THF/methanol/water (5/5/2 ml) to yield 100 mg (63.6% yield) of the titled compound. MS: m/z=560.9 (M+1).

1. customreaction conditions