HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → HCID 118524093, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | HCID 118523895 | HCID 118523895 | — |
| Reactant | 3-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-5-(4-(piperidin-4-yl)phenyl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine hydrochloride | HCID 118524085 | — |
| Solvent | Methanol tetrahydrofuran water | HCID 21892291 | — |
| Product | HCID 118524093 | HCID 118524093 | — |
Reaction Steps
Using similar reaction conditions as described in step-iii of example-1, tert-butyl 4-(4-(3-(1-phenethyl-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperazine-1-carboxylate (160 mg, 0.227 mmol) was hydrolyzed by lithium hydroxide (19 mg, 0.455 mmol), THF/Methanol/water (5/1/1 ml) to yield 130 mg (crude) of the titled compound. MS: m/z=549.4 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09353107B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-16a13fd05dac448cbda33edbe7eca721 |
| Source note | uspto-grants-2016_05 |