反应详情

Using similar reaction conditions as described in step-iii of example-1, tert-butyl 4-(4-(3-(1-phenethyl-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperazine-1-carboxylate (160 mg, 0.227 mmol) was hydrolyzed by lithium hydroxide (19 mg, 0.455 mmol), THF/Methanol/water (5/1/1 ml) to yield 130 mg (crude) of the titled compound. MS: m/z=549.4 (M+1).

1. customreaction conditions