HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 4-[2-(3,3-Dicyclohexyl-ureido)-4-methyl-thiazole-5-sulfonylamino]-piperidine-1-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | Dicyclohexylamine | HCID 7582 | — |
| Reactant | Ethyl 4-amino-1-piperidinecarboxylate | HCID 100867 | — |
| Reactant | 2-Acetamido-1,3-thiazole-5-sulfonyl chloride | HCID 350261 | — |
| Product | 4-[2-(3,3-Dicyclohexyl-ureido)-4-methyl-thiazole-5-sulfonylamino]-piperidine-1-carboxylic acid ethyl ester | HCID 57883629 | — |
| Product | 2-(3,3-Dicyclohexylureido)-4-methylthiazole-5-sulfonic acid piperidin-4-ylamide | HCID 57883859 | — |
Reaction Steps
4-[2-(3,3-Dicyclohexyl-ureido)-4-methyl-thiazole-5-sulfonylamino]-piperidine-1-carboxylic acid ethyl ester was prepared as described in Example 173 using ethyl 4-amino-1-piperidine carboxylate, dicyclohexylamine and 2-acetylamino-thiazole-5-sulfonyl chloride. Reaction with 33% HBr in acetic acid followed by chromatography afforded the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | USRE045183E1 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-5575f1b89a064cef8392e9264748b161 |
| Source note | uspto-grants-2014_10 |