HRID531940

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID176

Acetic Acid

C2H4O2

HCID260

Hydrogen Bromide

BrH

HCID7582

Dicyclohexylamine

C12H23N

HCID100867

Ethyl 4-amino-1-piperidinecarboxylate

C8H16N2O2

HCID350261

N-[5-(Chlorosulfonyl)-1,3-thiazol-2-yl]ethanimidic acid

C5H5ClN2O3S2

PRODUCTS

生成物

结构：CCOC(=O)N1CCC(NS(=O)(=O)c2sc(NC(=O)N(C3CCCCC3)C3CCCCC3)nc2C)CC1

HCID57883629

未命名化合物

结构：Cc1nc(NC(=O)N(C2CCCCC2)C2CCCCC2)sc1S(=O)(=O)NC1CCNCC1

HCID57883859

未命名化合物

PROCEDURE

实验过程

4-[2-(3,3-Dicyclohexyl-ureido)-4-methyl-thiazole-5-sulfonylamino]-piperidine-1-carboxylic acid ethyl ester was prepared as described in Example 173 using ethyl 4-amino-1-piperidine carboxylate, dicyclohexylamine and 2-acetylamino-thiazole-5-sulfonyl chloride. Reaction with 33% HBr in acetic acid followed by chromatography afforded the title compound.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-5575f1b89a064cef8392e9264748b161
来源数据集: uspto-grants-2014_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: USRE045183E1
来源说明: uspto-grants-2014_10

反应 SMILES

[NH2:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH2:4][CH2:3]1.[CH:13]1([NH:19][CH:20]2[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]2)[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1.[C:26]([NH:29][C:30]1[S:31][C:32]([S:35](Cl)(=[O:37])=[O:36])=[CH:33][N:34]=1)(=[O:28])C.Br.[C:40](O)(=O)C>>[CH2:11]([O:10][C:8]([N:5]1[CH2:4][CH2:3][CH:2]([NH:1][S:35]([C:32]2[S:31][C:30]([NH:29][C:26]([N:19]([CH:13]3[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]3)[CH:20]3[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25]3)=[O:28])=[N:34][C:33]=2[CH3:40])(=[O:37])=[O:36])[CH2:7][CH2:6]1)=[O:9])[CH3:12].[NH:5]1[CH2:4][CH2:3][CH:2]([NH:1][S:35]([C:32]2[S:31][C:30]([NH:29][C:26]([N:19]([CH:13]3[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]3)[CH:20]3[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25]3)=[O:28])=[N:34][C:33]=2[CH3:40])(=[O:37])=[O:36])[CH2:7][CH2:6]1