Urea → HCID 178461373, compound

HRID 531951Notes

Reaction equation

HRID 531951 reaction equation
N[C:2](N)=[O:3].[CH:5]1([NH:11][C@H:12]2[CH2:17][CH2:16][C@H:15]([CH3:18])[CH2:14][CH2:13]2)[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1.[NH2:19][C:20]1[S:21][C:22]([CH:25]=[O:26])=[CH:23][N:24]=1>>[CH:5]1([N:11]([C@H:12]2[CH2:13][CH2:14][C@H:15]([CH3:18])[CH2:16][CH2:17]2)[C:2]([NH:19][C:20]2[S:21][C:22]([CH:25]=[O:26])=[CH:23][N:24]=2)=[O:3])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10]1

Participants

4

Reactant 3

HCID 1176UreaHCID 27377982-Amino-1,3-thiazole-5-carbaldehydeHCID 178461295HCID 178461295, compound

Product 1

HCID 178461373HCID 178461373, compound

Procedure

Prepared in 40% (140 mg) yield as described for 1,1-dicyclohexyl-3-5-formyl-thiazol-2-yl)-urea using cyclohexyl-(trans-4-methyl-cyclohexyl)-amine (195 mg, 1.0 mmol) and 2-amino-5-formylthiazole (128 mg, 1.0 mmol).

Workup

  1. customPrepared in 40% (140 mg)
  2. customyield

Sources & evidence

ORD record
ord-309363124f3d47cca025cb26264f3543
Source dataset
uspto-grants-2014_10
Patent number
USRE045183E1

Reaction notes

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