Benzenesulfonyl chloride → HCID 57883485, compound

HRID 531983Notes

Reaction equation

HRID 531983 reaction equation
Cl.[CH:2]1([N:8]([CH:24]2[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]2)[C:9]([NH:11][C:12]2[S:13][C:14]([CH2:17][N:18]3[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]3)=[CH:15][N:16]=2)=[O:10])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.CCN(C(C)C)C(C)C.[C:39]1([S:45](Cl)(=[O:47])=[O:46])[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=1>>[C:39]1([S:45]([N:21]2[CH2:22][CH2:23][N:18]([CH2:17][C:14]3[S:13][C:12]([NH:11][C:9](=[O:10])[N:8]([CH:2]4[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]4)[CH:24]4[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]4)=[N:16][CH:15]=3)[CH2:19][CH2:20]2)(=[O:47])=[O:46])[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=1

Participants

4

Reactant 3

HCID 7369Benzenesulfonyl chlorideHCID 81531DiisopropylethylamineHCID 86761257HCID 86761257, compound

Product 1

HCID 57883485HCID 57883485, compoundYield 84.7%

Procedure

Prepared as described in general procedure (Q) using 1,1-dicyclohexyl-3 -(5-piperazin-1 -ylmethyl-thiazol-2-yl)-urea hydrochloride (36 mg, 0.08 mmol), DIEA (42 μL, 0.24 mmol) and benzenesulfonyl chloride (20 μL, 0.16 mmol) to afford 37 mg (68%) of the desired product after purification.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-37797d0453bc453399f80afbb5683292
Source dataset
uspto-grants-2014_10
Patent number
USRE045183E1

Reaction notes

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