Diisopropylethylamine → HCID 57883718, compound

HRID 531985Notes

Reaction equation

HRID 531985 reaction equation
Cl.[CH:2]1([N:8]([CH:24]2[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]2)[C:9]([NH:11][C:12]2[S:13][C:14]([CH2:17][N:18]3[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]3)=[CH:15][N:16]=2)=[O:10])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.CCN(C(C)C)C(C)C.[CH3:39][N:40]1[CH:44]=[C:43]([S:45](Cl)(=[O:47])=[O:46])[N:42]=[CH:41]1>>[CH:24]1([N:8]([CH:2]2[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]2)[C:9]([NH:11][C:12]2[S:13][C:14]([CH2:17][N:18]3[CH2:23][CH2:22][N:21]([S:45]([C:43]4[N:42]=[CH:41][N:40]([CH3:39])[CH:44]=4)(=[O:47])=[O:46])[CH2:20][CH2:19]3)=[CH:15][N:16]=2)=[O:10])[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1

Participants

4

Reactant 3

HCID 81531DiisopropylethylamineHCID 27368871-methyl-1H-imidazole-4-sulfonyl chlorideHCID 86761257HCID 86761257, compound

Product 1

HCID 57883718HCID 57883718, compoundYield 66.1%

Procedure

Prepared as described in general procedure (Q) using 1,1-dicyclohexyl-3-(5-piperazin-1-ylmethyl-thiazol-2-yl)-urea hydrochloride (27 mg, 0.055 mmol), DIEA (29 μL, 0.17 mmol) and N-methylimidazole-4-sulfonyl chloride (20 mg, 0.11 mmol) to afford 20 mg (66%) of the desired product after purification.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-96ed4b137bae497bbe6bb9b9eb360153
Source dataset
uspto-grants-2014_10
Patent number
USRE045183E1

Reaction notes

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