N-(tert-butoxycarbonyl)glycine → HCID 57883569, compound

HRID 532004Notes

Reaction equation

HRID 532004 reaction equation
[NH2:1][CH2:2][C:3]1[N:4]=[C:5]([NH:8][C:9](=[O:23])[N:10]([CH:17]2[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]2)[CH:11]2[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)[S:6][CH:7]=1.[C:24]([NH:31][CH2:32][C:33](O)=[O:34])([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25]>>[C:27]([O:26][C:24](=[O:25])[NH:31][CH2:32][C:33](=[O:34])[NH:1][CH2:2][C:3]1[N:4]=[C:5]([NH:8][C:9]([N:10]([CH:11]2[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)[CH:17]2[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]2)=[O:23])[S:6][CH:7]=1)([CH3:30])([CH3:28])[CH3:29]

Participants

3

Reactant 2

HCID 78288N-(tert-butoxycarbonyl)glycineHCID 86611207HCID 86611207, compound

Product 1

HCID 57883569HCID 57883569, compoundYield 29%

Procedure

Prepared in 29% yield (40 mg) as described in general procedure (K) from 3-(4-aminomethylthiazol-2-yl)-1,1-dicyclohexyl-urea (96 mg, 0.28 mmol) and Boc-glycine (60 mg, 0.30 mmol).

Workup

  1. customPrepared in 29% yield (40 mg)

Sources & evidence

ORD record
ord-f9bb0ff0d465428483fc0022d187c5cb
Source dataset
uspto-grants-2014_10
Patent number
USRE045183E1

Reaction notes

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