Ethyl Acetate → HCID 19082060, compound

HRID 53204Notes

Reaction equation

HRID 53204 reaction equation
CO[C:3]1[N:8]=[CH:7][C:6]([CH:9]=[CH:10][C:11]([O:13][CH3:14])=[O:12])=[CH:5][CH:4]=1.[H][H].[C:17](OCC)(=[O:19])C>[Pd]>[CH3:17][O:19][C:7]1[N:8]=[CH:3][CH:4]=[CH:5][C:6]=1[CH2:9][CH2:10][C:11]([O:13][CH3:14])=[O:12]

Participants

5

Reactant 3

HCID 8857Ethyl AcetateHCID 53929170Methyl beta-(2-methoxypyridin-5-yl)acrylateHCID 178418361HCID 178418361, compound

Product 1

HCID 19082060HCID 19082060, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

A suspension of methyl β-(6-methoxypyridin-3-yl)acrylate (3 g, 15.5 mmol) and 1 g of 5% Pd/C in 100 ml of ethyl acetate was hydrogenated under hydrogen (50 psi). After hydrogen uptake had ceased, the mixture was filtered through solka floc, the filtrate was concentrated in vacuo to afford 2.7 g (90%) of methyl 3-(6-methoxypyridin-5-yl)propionate.

Workup

  1. filtrationthe mixture was filtered through solka floc
  2. concentrationthe filtrate was concentrated in vacuo

Sources & evidence

ORD record
ord-7376c5a756354be1ba74096c48de4143
Source dataset
uspto-grants-1997_04
Patent number
US05618821

Reaction notes

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