Cyclohexanone → HCID 57883652, compound

HRID 532067Notes

Reaction equation

HRID 532067 reaction equation
[CH:1]1([NH2:7])[CH2:6][CH2:5][CH:4]=[CH:3][CH2:2]1.[C:8]1(=O)[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1.C1N=CN([C:20]([N:22]2[CH:26]=N[CH:24]=[CH:23]2)=[O:21])C=1.[Cl:27][C:28]1[S:32][C:31]([NH2:33])=[N:30][CH:29]=1>>[CH:1]1([NH:7][CH:8]2[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]2)[CH2:6][CH2:5][CH:4]=[CH:3][CH2:2]1.[Cl:27][C:28]1[S:32][C:31]([NH:33][C:20](=[O:21])[N:22]([CH:23]2[CH2:24][CH2:10][CH:9]=[CH:8][CH2:13]2)[CH:26]2[CH2:3][CH2:4][CH2:5][CH2:6][CH2:1]2)=[N:30][CH:29]=1

Participants

6

Reactant 4

HCID 7967CyclohexanoneHCID 389422-Amino-5-chlorothiazoleHCID 682631,1'-CarbonyldiimidazoleHCID 13040867HCID 13040867, compound

Product 2

HCID 57883652HCID 57883652, compoundHCID 65702898Cyclohex-3-enyl-cyclohexylamine

Procedure

Cyclohex-3-enyl-cyclohexylamine was prepared by reductive amination of cyclohex-3-enylamine and cyclohexanone using general procedure (B). Reaction with CDI and 5-chloro-2-aminothiazole using general procedure (A) gave the title compound.

Sources & evidence

ORD record
ord-ec65bd7fcae545e4a4ec09d2ccc75a5d
Source dataset
uspto-grants-2014_10
Patent number
USRE045183E1

Reaction notes

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