反应详情

A mixture of 2-(acetylimino)-3-(3-trifluoromethylphenyl)-5-methylthiazoline (1 g) and hydrochloric acid (38 %, 4 ml) in ethanol-water (1:2, 15 ml) was refluxed for 3 hours. Ethanol was removed by distillation under reduced pressure, and the residue was neutralized with potassium carbonate, extracted with ethyl acetate and dried over anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure to give 0.4 g of 2-imino-3-(3-trifluoromethylphenyl)-5-methylthiazoline (Compound (xi)).

1. temperaturewas refluxed for 3 hours
2. customEthanol was removed by distillation under reduced pressure
3. extractionextracted with ethyl acetate
4. dry with materialdried over anhydrous magnesium sulfate
5. customThe solvent was removed by distillation under reduced pressure