HCID 58413253, compound → HCID 58413331, compound

HRID 532265Notes

Reaction equation

HRID 532265 reaction equation
[N+:1]([C:4]1[C:5]([O:10][CH:11]([CH3:16])[C:12]([F:15])([F:14])[F:13])=[N:6][CH:7]=[CH:8][CH:9]=1)([O-])=O>CO.[Ni]>[F:15][C:12]([F:13])([F:14])[CH:11]([O:10][C:5]1[C:4]([NH2:1])=[CH:9][CH:8]=[CH:7][N:6]=1)[CH3:16]

Participants

4

Reactant 1

HCID 58413253HCID 58413253, compound

Product 1

HCID 58413331HCID 58413331, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

3-Nitro-2-(1,1,1-trifluoropropan-2-yloxy)pyridine (6.2 g) was dissolved in methanol (500 ml) and Raney nickel (1.0 g) was added. The reaction mixture was hydrogenated at room temperature and 5 bar. The catalyst was filtered off and the filtrate was concentrated in vacuo.

Workup

  1. customwas hydrogenated at room temperature
  2. filtrationThe catalyst was filtered off
  3. concentrationthe filtrate was concentrated in vacuo

Sources & evidence

ORD record
ord-99be2db461544b39b71a033ba3746a0d
Source dataset
uspto-grants-2014_10
Patent number
US08853193B2

Reaction notes

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