HCID 58413265, compound → HCID 58413388, compound

HRID 532270Notes

Reaction equation

HRID 532270 reaction equation
[N+:1]([C:4]1[C:5]([O:10][CH2:11][C:12]2([CH2:15][C:16]#[N:17])[CH2:14][CH2:13]2)=[N:6][CH:7]=[CH:8][CH:9]=1)([O-])=O>C(O)(=O)C.C(O)C>[NH2:1][C:4]1[C:5]([O:10][CH2:11][C:12]2([CH2:15][C:16]#[N:17])[CH2:14][CH2:13]2)=[N:6][CH:7]=[CH:8][CH:9]=1

Participants

4

Reactant 1

HCID 58413265HCID 58413265, compound

Product 1

HCID 58413388HCID 58413388, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 702EthanolSolvent

Conditions

Temperature
100 °C

Procedure

2-(1-((3-Nitropyridin-2-yloxy)methyl)cyclopropyl)acetonitrile (466 mg) was dissolved in a mixture of glacial acetic acid (4 ml) and ethanol (8 ml). Ferrum (1.1 g) was added and the reaction mixture was heated to 100° C. for 2 h. The mixture was concentrated in vacuo and the residue was dissolved in dichloromethane, extracted with an aqueous solution of K2CO3 (2M) and concentrated in vacuo

Workup

  1. additionFerrum (1.1 g) was added
  2. concentrationThe mixture was concentrated in vacuo
  3. dissolutionthe residue was dissolved in dichloromethane
  4. extractionextracted with an aqueous solution of K2CO3 (2M)
  5. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-fbc49b9bc15f46289377696a5fa1cada
Source dataset
uspto-grants-2014_10
Patent number
US08853193B2

Reaction notes

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