HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 4-Amino-3-(2-fluoro-1-fluoromethyl-ethoxy)-benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Stannous chloride dihydrate | HCID 61436 | — |
| Reactant | 3-(2-Fluoro-1-fluoromethyl-ethoxy)-4-nitro-benzonitrile | HCID 58413384 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-Amino-3-(2-fluoro-1-fluoromethyl-ethoxy)-benzonitrile | HCID 58413351 | — |
Reaction Steps
3-(2-Fluoro-1-fluoromethyl-ethoxy)-4-nitro-benzonitrile (1.45 g), tin(II) chloride dihydrate (4.00 g) and ethanol (60 ml) were stirred at 100° C. for 2 hours. The mixture was poured in water and extracted with DCM. The organic layer was washed with water, dried and concentrated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08853193B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-006395d279e3411ba7401ea99f8910e1 |
| Source note | uspto-grants-2014_10 |