Ethanol → 4-Amino-3-(2-fluoro-1-fluoromethyl-ethoxy)-benzonitrile

HRID 532274Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 532274
[F:1][CH2:2][CH:3]([CH2:16][F:17])[O:4][C:5]1[CH:6]=[C:7]([CH:10]=[CH:11][C:12]=1[N+:13]([O-])=O)[C:8]#[N:9].O.O.[Sn](Cl)Cl.C(O)C>O>[NH2:13][C:12]1[CH:11]=[CH:10][C:7]([C:8]#[N:9])=[CH:6][C:5]=1[O:4][CH:3]([CH2:2][F:1])[CH2:16][F:17]

Komponenten

5

Edukt 3

HCID 702EthanolHCID 61436Stannous chloride dihydrateHCID 584133843-(2-Fluoro-1-fluoromethyl-ethoxy)-4-nitro-benzonitrile

Produkt 1

HCID 584133514-Amino-3-(2-fluoro-1-fluoromethyl-ethoxy)-benzonitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

3-(2-Fluoro-1-fluoromethyl-ethoxy)-4-nitro-benzonitrile (1.45 g), tin(II) chloride dihydrate (4.00 g) and ethanol (60 ml) were stirred at 100° C. for 2 hours. The mixture was poured in water and extracted with DCM. The organic layer was washed with water, dried and concentrated.

Aufarbeitung

  1. extractionextracted with DCM
  2. washThe organic layer was washed with water
  3. customdried
  4. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-006395d279e3411ba7401ea99f8910e1
Quelldatensatz
uspto-grants-2014_10
Patentnummer
US08853193B2

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