Dichloromethane → HCID 67390007, compound

HRID 532278Notes

Reaction equation

HRID 532278 reaction equation
C(OC([NH:8][CH2:9][CH2:10][O:11][C:12]1[CH:17]=[C:16]([F:18])[CH:15]=[CH:14][C:13]=1[NH:19][C:20]1[C:21]2[C:28]([CH3:29])=[C:27]([C:30]([O:32][CH3:33])=[O:31])[S:26][C:22]=2[N:23]=[CH:24][N:25]=1)=O)(C)(C)C.[Cl:34]CCl>FC(F)(F)C(O)=O>[ClH:34].[NH2:8][CH2:9][CH2:10][O:11][C:12]1[CH:17]=[C:16]([F:18])[CH:15]=[CH:14][C:13]=1[NH:19][C:20]1[C:21]2[C:28]([CH3:29])=[C:27]([C:30]([O:32][CH3:33])=[O:31])[S:26][C:22]=2[N:23]=[CH:24][N:25]=1

Participants

4

Reactant 2

HCID 6344DichloromethaneHCID 58413398HCID 58413398, compound

Product 1

HCID 67390007HCID 67390007, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

Methyl 4-(2-(2-(tert-butoxycarbonylamino)ethoxy)-4-fluorophenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylate (20 mg) was dissolved in 25% solution of trifluoroacetic acid in dichlormethane (2 ml). The reaction was stirred at room temperature for 2 h. The solvent was concentrated in vacuo and the residue was dissolved in methanol and triturated with HCl in methanol.

Workup

  1. concentrationThe solvent was concentrated in vacuo
  2. dissolutionthe residue was dissolved in methanol
  3. customtriturated with HCl in methanol

Sources & evidence

ORD record
ord-6563f3d9756a4305a8f2457f83628931
Source dataset
uspto-grants-2014_10
Patent number
US08853193B2

Reaction notes

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