Sodium Hydroxide → HCID 58413296, compound

HRID 532284Notes

Reaction equation

HRID 532284 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[C:10]3[C:17]([CH3:18])=[C:16]([C:19]([O:21]C)=[O:20])[S:15][C:11]=3[N:12]=[CH:13][N:14]=2)=[C:4]([O:23][CH:24]([CH2:26][C:27]([OH:30])([CH3:29])[CH3:28])[CH3:25])[CH:3]=1.[OH-].[Na+]>CO>[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[C:10]3[C:17]([CH3:18])=[C:16]([C:19]([OH:21])=[O:20])[S:15][C:11]=3[N:12]=[CH:13][N:14]=2)=[C:4]([O:23][CH:24]([CH2:26][C:27]([OH:30])([CH3:29])[CH3:28])[CH3:25])[CH:3]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 58413378HCID 58413378, compound

Product 1

HCID 58413296HCID 58413296, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Methyl 4-(4-fluoro-2-(4-hydroxy-4-methylpentan-2-yloxy)phenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylate (710 mg) was dissolved in methanol (50 ml) and aqueous NaOH (4M; 5 ml) was added. The reaction was stirred at room temperature overnight and then heated at 60° C. for 2 h. Finally the solution was neutralised and concentrated in vacuo. The residue was triturated with water. The resultant precipitate was filtered and dried.

Workup

  1. temperatureheated at 60° C. for 2 h
  2. concentrationconcentrated in vacuo
  3. customThe residue was triturated with water
  4. filtrationThe resultant precipitate was filtered
  5. customdried

Sources & evidence

ORD record
ord-ad684e676ccb4c39b4602a58a21ef59a
Source dataset
uspto-grants-2014_10
Patent number
US08853193B2

Reaction notes

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