Sodium Hydroxide → HCID 58413296, compound

Participants

Reaction Steps

Methyl 4-(4-fluoro-2-(4-hydroxy-4-methylpentan-2-yloxy)phenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylate (710 mg) was dissolved in methanol (50 ml) and aqueous NaOH (4M; 5 ml) was added. The reaction was stirred at room temperature overnight and then heated at 60° C. for 2 h. Finally the solution was neutralised and concentrated in vacuo. The residue was triturated with water. The resultant precipitate was filtered and dried.

Provenance & Evidence