Cesium carbonate → HCID 58413232, compound

HRID 532298Notes

Reaction equation

[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[C:10]3[C:17]([CH3:18])=[C:16]([C:19]([O:21][CH3:22])=[O:20])[S:15][C:11]=3[N:12]=[CH:13][N:14]=2)=[C:4]([OH:23])[CH:3]=1.C(=O)([O-])[O-].[Cs+].[Cs+].[C:30]([O:34][C:35](=[O:39])[CH:36](Br)[CH3:37])([CH3:33])([CH3:32])[CH3:31]>C(#N)C>[CH3:22][O:21][C:19]([C:16]1[S:15][C:11]2[N:12]=[CH:13][N:14]=[C:9]([NH:8][C:5]3[CH:6]=[CH:7][C:2]([F:1])=[CH:3][C:4]=3[O:23][CH:36]([CH3:37])[C:35]([O:34][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:39])[C:10]=2[C:17]=1[CH3:18])=[O:20]

Participants

Conditions

Temperature: 60 °C

Procedure

Methyl 4-(4-fluoro-2-hydroxyphenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylate (100 mg) and Caesium carbonate (240 mg) was dissolved in acetonitrile (2 ml) and 2-bromopropionic acid tert-butylester (70 mg) was added. The reaction mixture was stirred at 60° C. for 2 h. Then the reaction was quenched with water and the precipitate was collected by filtration. The residue cake was washed with water and a few drops of methanol.

Workup

customThen the reaction was quenched with water
filtrationthe precipitate was collected by filtration
washThe residue cake was washed with water and a few drops of methanol

Sources & evidence

ORD record: ord-13bd7f8d7dd4429eb4ffd998c28dbf91
Source dataset: uspto-grants-2014_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08853193B2

Reaction notes

Loading…