HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 532298Generated: October 29, 2026
Cesium carbonate → HCID 58413232, compound
https://huagongshe.com/reaction/532298
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | tert-Butyl 2-bromopropanoate | HCID 545327 | — |
| Reactant | Methyl 4-(4-fluoro-2-hydroxyphenylamino)-5-methylthieno[2,3-d]pyrimidine-6-carboxylate | HCID 58413076 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 58413232 | HCID 58413232 | — |
Reaction Steps
Methyl 4-(4-fluoro-2-hydroxyphenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylate (100 mg) and Caesium carbonate (240 mg) was dissolved in acetonitrile (2 ml) and 2-bromopropionic acid tert-butylester (70 mg) was added. The reaction mixture was stirred at 60° C. for 2 h. Then the reaction was quenched with water and the precipitate was collected by filtration. The residue cake was washed with water and a few drops of methanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08853193B2 |
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| Source dataset | uspto-grants-2014_10 |
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| ORD ID | ord-13bd7f8d7dd4429eb4ffd998c28dbf91 |
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| Source note | uspto-grants-2014_10 |
|---|
