Trifluoroacetic acid → HCID 58413270, compound

HRID 532299Notes

Reaction equation

HRID 532299 reaction equation
[CH3:1][O:2][C:3]([C:5]1[S:31][C:8]2[N:9]=[CH:10][N:11]=[C:12]([NH:13][C:14]3[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=3[O:21][CH:22]([CH3:30])[C:23]([O:25]C(C)(C)C)=[O:24])[C:7]=2[C:6]=1[CH3:32])=[O:4].FC(F)(F)C(O)=O>ClCCl>[F:20][C:17]1[CH:18]=[CH:19][C:14]([NH:13][C:12]2[C:7]3[C:6]([CH3:32])=[C:5]([C:3]([O:2][CH3:1])=[O:4])[S:31][C:8]=3[N:9]=[CH:10][N:11]=2)=[C:15]([CH:16]=1)[O:21][CH:22]([CH3:30])[C:23]([OH:25])=[O:24]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 58413232HCID 58413232, compound

Product 1

HCID 58413270HCID 58413270, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Prepared analogously to example 8.1 using methyl-4-(2-(1-tert-butoxy-1-oxopropan-2-yloxy)-4-fluorophenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylate (2.1 g) and 50% trifluoroacetic acid in dichloromethane (20 ml).

Sources & evidence

ORD record
ord-5a0832e8191b4546a3fd964535e14984
Source dataset
uspto-grants-2014_10
Patent number
US08853193B2

Reaction notes

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