N,N-Dimethylethylenediamine → HCID 58413284, compound

HRID 532300Notes

Reaction equation

HRID 532300 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([NH:14][C:15]2[C:16]3[C:23]([CH3:24])=[C:22]([C:25]([O:27][CH3:28])=[O:26])[S:21][C:17]=3[N:18]=[CH:19][N:20]=2)=[C:6]([CH:13]=1)[O:7][CH:8]([CH3:12])[C:9](O)=[O:10].[CH3:29][N:30]([CH3:34])[CH2:31][CH2:32][NH2:33]>>[CH3:29][N:30]([CH3:34])[CH2:31][CH2:32][NH:33][C:9](=[O:10])[CH:8]([O:7][C:6]1[CH:13]=[C:2]([F:1])[CH:3]=[CH:4][C:5]=1[NH:14][C:15]1[C:16]2[C:23]([CH3:24])=[C:22]([C:25]([O:27][CH3:28])=[O:26])[S:21][C:17]=2[N:18]=[CH:19][N:20]=1)[CH3:12]

Participants

3

Reactant 2

HCID 66053N,N-DimethylethylenediamineHCID 58413270HCID 58413270, compound

Product 1

HCID 58413284HCID 58413284, compound

Procedure

Prepared analogously to example 32.3 from 2-(5-fluoro-2-(6-(methoxycarbonyl)-5-methylthieno[2,3-d]pyrimidin-4-ylamino)phenoxy)propanoic acid (200 mg) and 2-dimethylaminoethylamine (70 μl)

Sources & evidence

ORD record
ord-3303078ed03b426ea161ada950acb141
Source dataset
uspto-grants-2014_10
Patent number
US08853193B2

Reaction notes

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