Sodium Hydroxide → HCID 46182084, compound

HRID 532303Notes

Reaction equation

HRID 532303 reaction equation
[CH:1]([O:4][C:5]1[C:10]([NH:11][C:12]2[C:13]3[C:20]([CH3:21])=[C:19]([C:22]([O:24]C)=[O:23])[S:18][C:14]=3[N:15]=[CH:16][N:17]=2)=[CH:9][CH:8]=[CH:7][N:6]=1)([CH3:3])[CH3:2].[OH-].[Na+]>CO>[CH:1]([O:4][C:5]1[C:10]([NH:11][C:12]2[C:13]3[C:20]([CH3:21])=[C:19]([C:22]([OH:24])=[O:23])[S:18][C:14]=3[N:15]=[CH:16][N:17]=2)=[CH:9][CH:8]=[CH:7][N:6]=1)([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 58413283HCID 58413283, compound

Product 1

HCID 46182084HCID 46182084, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
60 °C

Procedure

Methyl 4-(2-isopropoxypyridin-3-ylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylate (2.04 g) was dissolved in methanol (24.0 ml), NaOH (2M; 6.0 ml) was added and the mixture was stirred at 60° C. for 1 h. Then the reaction was cooled and washed with dichloromethane. The aqueous layer was acidified to pH 5 with conc. HCl and the precipitate was filtered and washed with water.

Workup

  1. temperatureThen the reaction was cooled
  2. washwashed with dichloromethane
  3. filtrationthe precipitate was filtered
  4. washwashed with water

Sources & evidence

ORD record
ord-47ace3308af248048c4862f2eafa291d
Source dataset
uspto-grants-2014_10
Patent number
US08853193B2

Reaction notes

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