Sodium Hydroxide → HCID 46182084, compound

Participants

Reaction Conditions

Reaction Steps

Methyl 4-(2-isopropoxypyridin-3-ylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylate (2.04 g) was dissolved in methanol (24.0 ml), NaOH (2M; 6.0 ml) was added and the mixture was stirred at 60° C. for 1 h. Then the reaction was cooled and washed with dichloromethane. The aqueous layer was acidified to pH 5 with conc. HCl and the precipitate was filtered and washed with water.

Provenance & Evidence