Potassium Carbonate → 6-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3-amine

HRID 532341Notes

Reaction equation

HRID 532341 reaction equation
Br.[Cl:2][C:3]1[CH:4]=[CH:5][C:6]2[N:7]([C:9]([NH2:12])=[N:10][N:11]=2)[N:8]=1.C(=O)([O-])[O-].[K+].[K+]>O>[Cl:2][C:3]1[CH:4]=[CH:5][C:6]2[N:7]([C:9]([NH2:12])=[N:10][N:11]=2)[N:8]=1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 866507946-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3-ylamine hydrobromide

Product 1

HCID 151078816-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3-amineYield 30.6%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

6-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3-ylamine hydrobromide (W2.001; 1.1 g) was taken up with a large amount of water and alkalized with saturated potassium carbonate solution. The solid which precipitated out was filtered off with suction and dried (388 mg). Repeated extraction of the mother liquor with dichloromethane, drying of the combined organic phases over sodium sulfate, filtration and concentration afforded a further 228 mg of product in total.

Workup

  1. customThe solid which precipitated out
  2. filtrationwas filtered off with suction
  3. customdried (388 mg)
  4. extractionextraction of the mother liquor with dichloromethane
  5. dry with materialdrying of the combined organic phases over sodium sulfate, filtration and concentration

Sources & evidence

ORD record
ord-c3ec3146d28844308ced0c5dc4595892
Source dataset
uspto-grants-2014_10
Patent number
US08853206B2

Reaction notes

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