反应详情

A solution of N-Benzyl-3-acetyl-3-(4-chlorobenzyl)-piperidine (492 mg, 1.44 mmol) and dimethyl oxalate (201 mg, 1.7 mmol) in dimethoxyethane (20 mL) was treated with sodium hydride (140 mg of a 60% dispersion in mineral oil, 3.4 mmol) and heated to reflux for 5 hours. The reaction was then cooled to room temperature, poured into saturated sodium bicarbonate (100 mL) and extracted with ethyl acetate (3×100 mL). The combined extracts were dried over anhydrous magnesium sulfate, filtered, and concentrated at reduced pressure. The crude ester thus obtained was purified by chromato-graphy on silica gel eluting with 10% methanol/chloroform. The material thus obtained was dissolved in tetrahydrofuran (5 mL) and 3N HCl (20 mL) and heated to reflux for 1 hour. The reaction was then cooled to room temperature, and concentrated at reduced pressure. The residue was triturated with tetrahydrofuran and the solid collected by filtration and crystallized from isopropanol to give 35 mg of the title compound. mp. 160°-165° C.

1. temperatureheated
2. temperatureto reflux for 5 hours
3. extractionextracted with ethyl acetate (3×100 mL)
4. dry with materialThe combined extracts were dried over anhydrous magnesium sulfate
5. filtrationfiltered
6. concentrationconcentrated at reduced pressure
7. customThe crude ester thus obtained
8. customwas purified by chromato-graphy on silica gel eluting with 10% methanol/chloroform
9. customThe material thus obtained
10. temperatureto reflux for 1 hour
11. temperatureThe reaction was then cooled to room temperature
12. concentrationconcentrated at reduced pressure
13. customThe residue was triturated with tetrahydrofuran
14. filtrationthe solid collected by filtration
15. customcrystallized from isopropanol