HCID 68944112, compound → HCID 68943596, compound

HRID 532428Notes

Reaction equation

HRID 532428 reaction equation
[CH3:1][N:2]1[CH:7]2[CH2:8][CH2:9][CH:3]1[CH2:4][CH:5]([O:10][C:11]1[CH:16]=[CH:15][C:14]([N+:17]([O-])=O)=[CH:13][C:12]=1[CH3:20])[CH2:6]2>CO.[Pd]>[CH3:20][C:12]1[CH:13]=[C:14]([NH2:17])[CH:15]=[CH:16][C:11]=1[O:10][CH:5]1[CH2:6][CH:7]2[N:2]([CH3:1])[CH:3]([CH2:9][CH2:8]2)[CH2:4]1

Participants

4

Reactant 1

HCID 68944112HCID 68944112, compound

Product 1

HCID 68943596HCID 68943596, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A suspension of 8-Methyl-3-(2-methyl-4-nitro-phenoxy)-8-aza-bicyclo[3.2.1]octane (495 mg) and palladium (5% on carbon; 63 mg) in methanol (25 mL) was stirred vigorously under a hydrogen atmosphere (atmospheric pressure) for 2 h. Then the catalyst was filtered off and the filtrate concentrated. The product with the molecular weight of 246.35 (C15H22N20); was obtained in this way; MS (ESI) 247 (M+H+).

Workup

  1. filtrationThen the catalyst was filtered off
  2. concentrationthe filtrate concentrated
  3. customwas obtained in this way

Sources & evidence

ORD record
ord-1c76ada4141f441eaf435d59b03552d8
Source dataset
uspto-grants-2014_10
Patent number
US08853208B2

Reaction notes

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