3-Fluoro-4-(2-(pyrrolidin-1-yl)ethoxy)aniline → 3-[3-Fluoro-4-(2-pyrrolidin-1-ylethoxy)phenyl]-6-(3-hydroxy-4-methylpentyl)-3H-thieno[3,2-d]pyrimidin-4-one

HRID 532434Notes

Reaction equation

HRID 532434 reaction equation
CO[C:3]([C:5]1[S:6][C:7]([CH2:15][CH2:16][CH:17]([OH:21])[CH:18]([CH3:20])[CH3:19])=[CH:8][C:9]=1[N:10]=[CH:11][N:12]([CH3:14])C)=[O:4].[F:22][C:23]1[CH:24]=C(N)[CH:26]=[CH:27][C:28]=1[O:29][CH2:30][CH2:31][N:32]1[CH2:36][CH2:35][CH2:34][CH2:33]1>>[F:22][C:23]1[CH:24]=[C:14]([N:12]2[C:3](=[O:4])[C:5]3[S:6][C:7]([CH2:15][CH2:16][CH:17]([OH:21])[CH:18]([CH3:19])[CH3:20])=[CH:8][C:9]=3[N:10]=[CH:11]2)[CH:26]=[CH:27][C:28]=1[O:29][CH2:30][CH2:31][N:32]1[CH2:33][CH2:34][CH2:35][CH2:36]1

Participants

3

Reactant 2

HCID 196272463-Fluoro-4-(2-(pyrrolidin-1-yl)ethoxy)anilineHCID 689393853-(Dimethylaminomethyleneamino)-5-(3-hydroxy-4-methylpentyl)thiophene-2-carboxylic acid methyl ester

Product 1

HCID 576188113-[3-Fluoro-4-(2-pyrrolidin-1-ylethoxy)phenyl]-6-(3-hydroxy-4-methylpentyl)-3H-thieno[3,2-d]pyrimidin-4-one

Procedure

3-(Dimethylaminomethyleneamino)-5-(3-hydroxy-4-methylpentyl)thiophene-2-carboxylic acid methyl ester was reacted with 3-fluoro-4-(2-pyrrolidin-1-ylethoxy)phenylamine by method A. The product with the molecular weight of 459.58 (C24H30FN3O3S) was obtained in this way; MS (ESI): 460 (M+H+).

Workup

  1. customThe product with the molecular weight of 459.58 (C24H30FN3O3S) was obtained in this way

Sources & evidence

ORD record
ord-478a1dab51a642bd9a3231a1eddae566
Source dataset
uspto-grants-2014_10
Patent number
US08853208B2

Reaction notes

Loading…