HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluoro-4-(2-(pyrrolidin-1-yl)ethoxy)aniline → 3-[3-Fluoro-4-(2-pyrrolidin-1-ylethoxy)phenyl]-6-(3-hydroxy-4-methylpentyl)-3H-thieno[3,2-d]pyrimidin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluoro-4-(2-(pyrrolidin-1-yl)ethoxy)aniline | HCID 19627246 | — |
| Reactant | 3-(Dimethylaminomethyleneamino)-5-(3-hydroxy-4-methylpentyl)thiophene-2-carboxylic acid methyl ester | HCID 68939385 | — |
| Product | 3-[3-Fluoro-4-(2-pyrrolidin-1-ylethoxy)phenyl]-6-(3-hydroxy-4-methylpentyl)-3H-thieno[3,2-d]pyrimidin-4-one | HCID 57618811 | — |
Reaction Steps
3-(Dimethylaminomethyleneamino)-5-(3-hydroxy-4-methylpentyl)thiophene-2-carboxylic acid methyl ester was reacted with 3-fluoro-4-(2-pyrrolidin-1-ylethoxy)phenylamine by method A. The product with the molecular weight of 459.58 (C24H30FN3O3S) was obtained in this way; MS (ESI): 460 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08853208B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-478a1dab51a642bd9a3231a1eddae566 |
| Source note | uspto-grants-2014_10 |