p-Fluoronitrobenzene → 8-(3-Fluoropropyl)-3-(4-nitrophenoxy)-8-azabicyclo[3.2.1]octane

HRID 532436Notes

Reaction equation

HRID 532436 reaction equation
[F:1][CH2:2][CH2:3][CH2:4][N:5]1[CH:10]2[CH2:11][CH2:12][CH:6]1[CH2:7][CH:8]([OH:13])[CH2:9]2.F[C:15]1[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][CH:16]=1>>[F:1][CH2:2][CH2:3][CH2:4][N:5]1[CH:10]2[CH2:11][CH2:12][CH:6]1[CH2:7][CH:8]([O:13][C:15]1[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][CH:16]=1)[CH2:9]2

Participants

3

Reactant 2

HCID 9590p-FluoronitrobenzeneHCID 689414078-(3-Fluoropropyl)-8-azabicyclo[3.2.1]octan-3-ol

Product 1

HCID 689432258-(3-Fluoropropyl)-3-(4-nitrophenoxy)-8-azabicyclo[3.2.1]octane

Procedure

8-(3-Fluoropropyl)-8-azabicyclo[3.2.1]octan-3-ol was reacted with 1-fluoro-4-nitrobenzene by method D. The product with the molecular weight of 308.35 (C16H21FN2O3) was obtained in this way; MS (ESI): 308 (M+H+).

Workup

  1. customThe product with the molecular weight of 308.35 (C16H21FN2O3) was obtained in this way

Sources & evidence

ORD record
ord-c23de2dd4a2a4ffe8816665fccaa5477
Source dataset
uspto-grants-2014_10
Patent number
US08853208B2

Reaction notes

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