HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 532437Generated: October 26, 2026
Triethylamine → 8-(3-Fluoropropyl)-8-azabicyclo[3.2.1]octan-3-ol
https://huagongshe.com/reaction/532437
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Propane, 1-bromo-3-fluoro- | HCID 67699 | — |
| Reactant | Nortropine | HCID 73480 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 8-(3-Fluoropropyl)-8-azabicyclo[3.2.1]octan-3-ol | HCID 68941407 | — |
Reaction Steps
A mixture of nortropine (381.6 mg), 1-bromo-3-fluoropropane (634.4 mg) and triethylamine (0.42 ml) in DMF (7.5 ml) was heated to 60° C. and stirred at this temperature for 10 h. The solvent was then removed in vacuo. The product with the molecular weight of 187.26 (C10H18FNO) was obtained in this way; MS (ESI): 188 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08853208B2 |
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| Source dataset | uspto-grants-2014_10 |
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| ORD ID | ord-a2c7dc60666d499b9c964627a2edf6d7 |
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| Source note | uspto-grants-2014_10 |
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