1-Pyrrolidineethanol → 1-[2-(2-Fluoro-4-nitrophenoxy)ethyl]pyrrolidine

HRID 532442Notes

Reaction equation

HRID 532442 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([N+:9]([O-:11])=[O:10])[CH:5]=[CH:6][C:7]=1F.[OH:12][CH2:13][CH2:14][N:15]1[CH2:19][CH2:18][CH2:17][CH2:16]1>>[F:1][C:2]1[CH:3]=[C:4]([N+:9]([O-:11])=[O:10])[CH:5]=[CH:6][C:7]=1[O:12][CH2:13][CH2:14][N:15]1[CH2:19][CH2:18][CH2:17][CH2:16]1

Participants

3

Reactant 2

HCID 762881-PyrrolidineethanolHCID 1230531,2-Difluoro-4-nitrobenzene

Product 1

HCID 252487661-[2-(2-Fluoro-4-nitrophenoxy)ethyl]pyrrolidine

Procedure

3,4-Difluoronitrobenzene was reacted with 1-(2-hydroxyethyl)pyrrolidine by method D1. The product with the molecular weight of 254.26 (C12H15FN2O3) was obtained in this way; MS (ESI): 255 (M+H+).

Workup

  1. customThe product with the molecular weight of 254.26 (C12H15FN2O3) was obtained in this way

Sources & evidence

ORD record
ord-d435328e97c14320be2455ff80b7337d
Source dataset
uspto-grants-2014_10
Patent number
US08853208B2

Reaction notes

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