2-Pyrrolidone → 3-[3-Fluoro-4-(2-pyrrolidin-1-ylethoxy)phenyl]-6-(2-oxopyrrolidin-1-yl)-3H-thieno[3,2-d]pyrimidin-4-one

HRID 532443Notes

Reaction equation

HRID 532443 reaction equation
Br[C:2]1[S:10][C:9]2[C:8](=[O:11])[N:7]([C:12]3[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][N:21]4[CH2:25][CH2:24][CH2:23][CH2:22]4)=[C:14]([F:26])[CH:13]=3)[CH:6]=[N:5][C:4]=2[CH:3]=1.[NH:27]1[CH2:31][CH2:30][CH2:29][C:28]1=[O:32]>>[F:26][C:14]1[CH:13]=[C:12]([N:7]2[C:8](=[O:11])[C:9]3[S:10][C:2]([N:27]4[CH2:31][CH2:30][CH2:29][C:28]4=[O:32])=[CH:3][C:4]=3[N:5]=[CH:6]2)[CH:17]=[CH:16][C:15]=1[O:18][CH2:19][CH2:20][N:21]1[CH2:25][CH2:24][CH2:23][CH2:22]1

Participants

3

Reactant 2

HCID 120252-PyrrolidoneHCID 689365036-Bromo-3-[3-fluoro-4-(2-pyrrolidin-1-ylethoxy)phenyl]-3H-thieno[3,2-d]pyrimidin-4-one

Product 1

HCID 576186943-[3-Fluoro-4-(2-pyrrolidin-1-ylethoxy)phenyl]-6-(2-oxopyrrolidin-1-yl)-3H-thieno[3,2-d]pyrimidin-4-one

Procedure

6-Bromo-3-[3-fluoro-4-(2-pyrrolidin-1-ylethoxy)phenyl]-3H-thieno[3,2-d]pyrimidin-4-one was reacted with 2-pyrrolidone by method S. The product with the molecular weight of 442.52 (C22H23FN4O3S) was obtained in this way; MS (ESI): 443 (M+H+).

Workup

  1. customThe product with the molecular weight of 442.52 (C22H23FN4O3S) was obtained in this way

Sources & evidence

ORD record
ord-372dc423f15a4295a83cbf8331158780
Source dataset
uspto-grants-2014_10
Patent number
US08853208B2

Reaction notes

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