HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Pyrrolidone → 3-[3-Fluoro-4-(2-pyrrolidin-1-ylethoxy)phenyl]-6-(2-oxopyrrolidin-1-yl)-3H-thieno[3,2-d]pyrimidin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Pyrrolidone | HCID 12025 | — |
| Reactant | 6-Bromo-3-[3-fluoro-4-(2-pyrrolidin-1-ylethoxy)phenyl]-3H-thieno[3,2-d]pyrimidin-4-one | HCID 68936503 | — |
| Product | 3-[3-Fluoro-4-(2-pyrrolidin-1-ylethoxy)phenyl]-6-(2-oxopyrrolidin-1-yl)-3H-thieno[3,2-d]pyrimidin-4-one | HCID 57618694 | — |
Reaction Steps
6-Bromo-3-[3-fluoro-4-(2-pyrrolidin-1-ylethoxy)phenyl]-3H-thieno[3,2-d]pyrimidin-4-one was reacted with 2-pyrrolidone by method S. The product with the molecular weight of 442.52 (C22H23FN4O3S) was obtained in this way; MS (ESI): 443 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08853208B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-372dc423f15a4295a83cbf8331158780 |
| Source note | uspto-grants-2014_10 |