HCID 57618669, compound → HCID 57618714, compound

HRID 532452Notes

Reaction equation

HRID 532452 reaction equation
[CH2:1]([O:3]/[CH:4]=[CH:5]\[C:6]1[S:14][C:13]2[C:12](=[O:15])[N:11]([C:16]3[CH:21]=[CH:20][C:19]([O:22][CH2:23][CH2:24][N:25]4[CH2:29][CH2:28][CH2:27][CH2:26]4)=[C:18]([F:30])[CH:17]=3)[CH:10]=[N:9][C:8]=2[CH:7]=1)[CH3:2]>[Pd].CO>[CH2:1]([O:3][CH2:4][CH2:5][C:6]1[S:14][C:13]2[C:12](=[O:15])[N:11]([C:16]3[CH:21]=[CH:20][C:19]([O:22][CH2:23][CH2:24][N:25]4[CH2:29][CH2:28][CH2:27][CH2:26]4)=[C:18]([F:30])[CH:17]=3)[CH:10]=[N:9][C:8]=2[CH:7]=1)[CH3:2]

Participants

4

Reactant 1

HCID 57618669HCID 57618669, compound

Product 1

HCID 57618714HCID 57618714, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Palladium on carbon (40 mg) was added to a solution of 6-((Z)-2-ethoxyvinyl)-3-[3-fluoro-4-(2-pyrrolidin-1-ylethoxy)phenyl]-3H-thieno[3,2-d]pyrimidin-4-one (73 mg) in methanol (4 mL), and the mixture was hydrogenated until starting material was no longer present. The mixture was filtered and the filtrate was concentrated. The product with the molecular weight of 431.53 (C22H26FN3O3S) was obtained in this way; MS (ESI): 432 (M+H+).

Workup

  1. filtrationThe mixture was filtered
  2. concentrationthe filtrate was concentrated
  3. customThe product with the molecular weight of 431.53 (C22H26FN3O3S) was obtained in this way

Sources & evidence

ORD record
ord-a81455eac8f447ab8a33fdc26b44e489
Source dataset
uspto-grants-2014_10
Patent number
US08853208B2

Reaction notes

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