HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 532462Generated: October 27, 2026
Formamide → 3H,4H-thieno[3,2-d]pyrimidin-4-one
https://huagongshe.com/reaction/532462
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formamide | HCID 713 | — |
| Reactant | Methyl 3-amino-2-thiophenecarboxylate | HCID 89652 | — |
| Product | 3H,4H-thieno[3,2-d]pyrimidin-4-one | HCID 135417422 | — |
Reaction Steps
Methyl-3-aminothiophene-2-carboxylate (15 g, 98.6 m mol) (Matrix, Cat #018289, CAS [22288-78-4]) was dissolved in formamide (50 mL) and stirred at 180° C. for 5 hours. The reaction mixture was further stirred at room temperature for 2 hours and the solid thus obtained was filtered to obtain the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08853213B2 |
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| Source dataset | uspto-grants-2014_10 |
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| ORD ID | ord-3a5ee5f021a040ec89313d9b43cd3a7e |
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| Source note | uspto-grants-2014_10 |
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