Formamide → 3H,4H-thieno[3,2-d]pyrimidin-4-one

HRID 532462Notes

Reaction equation

HRID 532462 reaction equation
C[O:2][C:3]([C:5]1[S:6][CH:7]=[CH:8][C:9]=1[NH2:10])=O.[CH:11]([NH2:13])=O>>[N:10]1[C:9]2[CH:8]=[CH:7][S:6][C:5]=2[C:3](=[O:2])[NH:13][CH:11]=1

Participants

3

Reactant 2

HCID 713FormamideHCID 89652Methyl 3-amino-2-thiophenecarboxylate

Product 1

HCID 1354174223H,4H-thieno[3,2-d]pyrimidin-4-one

Conditions

Temperature
180 °C

Procedure

Methyl-3-aminothiophene-2-carboxylate (15 g, 98.6 m mol) (Matrix, Cat #018289, CAS [22288-78-4]) was dissolved in formamide (50 mL) and stirred at 180° C. for 5 hours. The reaction mixture was further stirred at room temperature for 2 hours and the solid thus obtained was filtered to obtain the title compound.

Workup

  1. stirringThe reaction mixture was further stirred at room temperature for 2 hours
  2. customthe solid thus obtained
  3. filtrationwas filtered

Sources & evidence

ORD record
ord-3a5ee5f021a040ec89313d9b43cd3a7e
Source dataset
uspto-grants-2014_10
Patent number
US08853213B2

Reaction notes

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