HRID53248

反应详情

EQUATION

反应方程式

REACTANTS

反应物

$结构：O=C(O)/C=C\C(=O)O$

HCID444266

Maleic acid

C4H4O4

结构：Cc1noc(-c2ccccc2N(C)C(=O)OC2CCN(CCNCS(C)(=O)=O)CC2)n1

HCID86750684

未命名化合物

PRODUCTS

生成物

$结构：Cc1noc(-c2ccccc2N(C)C(=O)OC2CCN(CCNCS(C)(=O)=O)CC2)n1.O=C(O)/C=C\C(=O)O$

HCID86750683

未命名化合物

收率 73.8%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8857

Ethyl acetate

C4H8O2

2 次

PROCEDURE

实验过程

[1-[2-[(Methylsulphonyl)methylamino]ethyl]-4-piperidinyl]methyl[2-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl]carbamate (55 mg) was dissolved in boiling ethyl acetate (1 ml) and maleic acid (17 mg) in hot ethyl acetate (1 ml) added. White crystals precipitated. These were filtered and dried under vacuum to give the title compound (51 mg), as a white powder, m.p. 170°-172°

WORKUP

后处理

additionadded
customWhite crystals precipitated
filtrationThese were filtered
customdried under vacuum

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a175068cb1484a3e8e9a7acf931dcddd
来源数据集: uspto-grants-1997_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05618827
来源说明: uspto-grants-1997_04

反应 SMILES

[CH3:1][S:2]([CH2:5][NH:6][CH2:7][CH2:8][N:9]1[CH2:14][CH2:13][CH:12]([O:15][C:16](=[O:31])[N:17]([CH3:30])[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[C:24]2[O:28][N:27]=[C:26]([CH3:29])[N:25]=2)[CH2:11][CH2:10]1)(=[O:4])=[O:3].[C:32]([OH:39])(=[O:38])/[CH:33]=[CH:34]\[C:35]([OH:37])=[O:36]>C(OCC)(=O)C>[C:32]([OH:39])(=[O:38])/[CH:33]=[CH:34]\[C:35]([OH:37])=[O:36].[CH3:1][S:2]([CH2:5][NH:6][CH2:7][CH2:8][N:9]1[CH2:14][CH2:13][CH:12]([O:15][C:16](=[O:31])[N:17]([CH3:30])[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[C:24]2[O:28][N:27]=[C:26]([CH3:29])[N:25]=2)[CH2:11][CH2:10]1)(=[O:4])=[O:3]