Trifluoroacetic acid → 5-methyl-7-(4-methanesulfonyl-phenyl)-4-(piperidin-4-yloxy)-5H-pyrrolo[3,2-d]pyrimidine

Participants

Reaction Steps

To tert-butyl 4-(5-methyl-7-(4-methanesulfonyl-phenyl)-5H-pyrrolo[3,2-d]pyrimidin-4-yloxy)piperidine-1-carboxylate obtained in Example 25, dichloromethane (1 mL) and trifluoroacetic acid (1 mL) were added, and stirred for 1 hour. After completion of the reaction, the reaction was terminated with saturated sodium bicarbonate, and dichloromethane layer was extracted and washed with a saline solution. Subsequently, the washed layer was dried over anhydrous sodium sulfate, and filtered and distilled under reduced pressure to obtain the title compound.

Provenance & Evidence