反应详情

To tert-butyl 4-(5-methyl-7-(4-methanesulfonyl-phenyl)-5H-pyrrolo[3,2-d]pyrimidin-4-yloxy)piperidine-1-carboxylate obtained in Example 25, dichloromethane (1 mL) and trifluoroacetic acid (1 mL) were added, and stirred for 1 hour. After completion of the reaction, the reaction was terminated with saturated sodium bicarbonate, and dichloromethane layer was extracted and washed with a saline solution. Subsequently, the washed layer was dried over anhydrous sodium sulfate, and filtered and distilled under reduced pressure to obtain the title compound.

1. customAfter completion of the reaction
2. customthe reaction was terminated with saturated sodium bicarbonate, and dichloromethane layer
3. extractionwas extracted
4. washwashed with a saline solution
5. dry with materialSubsequently, the washed layer was dried over anhydrous sodium sulfate
6. filtrationfiltered
7. distillationdistilled under reduced pressure